Our game was played at 300 points, using a trio of my ninja turtles against Shredder and some of his Foot clan ninja. The turtles were all pointed up as protagonists in an attempt to see if it would work. The rules intend that a list only has one protagonist, one bruiser and any number of extras.
The main benefit of a protagonist is the ability to react to failed activation rolls. With more than one protagonist on my turtle list, even though they were heavily outnumbered, they were able to react with deadly intent several times during my opponent's turn. The game was fun, and it was a good learning opportunity, but I will definitely be revising the lists to make things feel more balanced.
Here are the lists we used:
Amphibious, Armour, Aura of the Tiger, Evade and Counter, Protected, Stealth
Amphibious, Armour, Boiling Blood, Dashing, Protected
Acrobat, Amphibious, Armour, Flurry of Blows, Protected
We didn't use him, but here is the profile for Donatello as well.
Amphibious, Armour, Aggressive Tumble, Protected, Throwing Stars
Armour, Backstabbing, Evade and Counter, Flurry of Blows, Group Fighter, Low Kick, Signature Weapon
Crimson Oni (57pts)
Acrobat, Dashing, Southern Dragon Claw, Steadfast
Acrobat, Dashing, Sneaky
Acrobat, Dashing, Poison
Acrobat, Throwing Stars
I reworked the turtle list to see if reducing them all to bruisers will still be playable without being overpowered. I ended up with Splinter being the protagonist and Casey and April as extras. I'm not sure I like it, but I'll have to play it and see how it shakes down.